The Liu Lab

Structural Interactomics

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Proteins and their interaction networks

Nearly every process in the living cell is based on proteins. To precisely execute this plethora of tasks, proteins are highly organized in a variety of assemblies, ranging from stable protein complexes, well-regulated pathways, to extended protein interaction networks. Perturbation of these well-balanced systems is linked to many different physiological and pathological conditions.

Our group is interested in developing and applying tools to characterize the complexity of protein interactions within the cell. Using state-of-the-art mass spectrometric technologies, in particular cross-linking mass spectrometry (XL-MS), we aim to gain a better understanding of protein interactomes in complex biological systems. This allows us to unravel how proteins are spatially organized and dynamically regulated in native cellular context, which is fundamental to the understanding of the molecular physiology of the cell.


our publications

Read about our work here!

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Opportunities for students

We are currently looking for master and PhD students in biochemistry, molecular biology, cell biology, bioinformatics and related fields. The projects involve novel mass spectrometry method development and/or organellar interactomic profiling using multi-disciplinary approaches. We provide an international, innovative and interdisciplinary work environment, with access to a state-of-the-art mass spectrometry platform as well as a range of molecular biology and cell biology techniques.

Cross-linking mass spectrometry provides unprecedented insights into protein assemblies and the interaction landscape.


Dr. Fan Liu

Phone: +49 (0)30 94793 141