Liu F*, Lössl P*, Rabbitts BM*, Balaban RS#, Heck AJ#. The interactome of intact mitochondria by cross-linking mass spectrometry provides evidence for co-existing respiratory supercomplexes. Molecular and Cellular Proteomics (DOI: 10.1074/mcp.RA117.000470)


Liu Q, Remmelzwaal S, Heck AJ, Akhmanova A#,Liu F#. Facilitating identification of minimal protein binding domains by cross-linking mass spectrometry. Scientific Reports (DOI: 10.1038/s41598-017-13663-y)

Liu F#*, Lossl P*, Scheltema R, Viner R, Heck AJ#. Optimized fragmentation schemes and data analysis strategies for proteome-wide cross-link identification. Nature Communications (DOI: 10.1038/ncomms15473)


Yang Y*, Liu F*, Franc V*, Halim LA, Schellekens H, Heck AJ. Hybrid mass spectrometry approaches in glycoprotein analysis and their usage in scoring biosimilarity. Nature Communications (DOI: 10.1038/ncomms13397)

Liu Q, Liu F, Yu KL, Tas R, Grigoriev I, Remmelzwaal S, Serra-Marques A, Kapitein LC, Heck AJR, Akhmanova A. MICAL3 Flavoprotein Monooxygenase Forms a Complex with Centralspindlin and Regulates Cytokinesis. Journal of Biological Chemistry (DOI: 10.1074/jbc.M116.748186)

Lössl P, Brunner AM, Liu F, Leney AC, Yamashita M, Scheltema RA, Heck AJ. Deciphering the Interplay among Multisite Phosphorylation, Interaction Dynamics, and Conformational Transitions in a Tripartite Protein System. ACS Central Science (DOI: 10.1021/acscentsci.6b00053)


Liu F, Rijkers DT, Post H, Heck AJ. Proteome-wide profiling of protein assemblies by cross-linking mass spectrometry. Nature Methods (DOI: 10.1038/nmeth.3603)

Liu F, Heck AJ. Interrogating the architecture of protein assemblies and protein interaction networks by cross-linking mass spectrometry. Current Opinion in Structural Biology (DOI: 10.1016/j.sbi.2015.10.006)

Glas M, van den Berg van Saparoea HB, McLaughlin SH, Roseboom W, Liu F, Koningstein GM, Fish A, den Blaauwen T, Heck AJ, de Jong L, Bitter W, de Esch IJ, Luirink J. The Soluble Periplasmic Domains of Escherichia coli Cell Division Proteins FtsQ/FtsB/FtsL Form a Trimeric Complex with Submicromolar Affinity. Journal of Biological Chemistry (DOI: 10.1074/jbc.M115.654756)

Argo AS, Shi C, Liu F, Goshe MB. Performing protein crosslinking using gas-phase cleavable chemical crosslinkers and liquid chromatography-tandem mass spectrometry. Methods (DOI: 10.1016/j.ymeth.2015.06.011)

Brunner AM, Lössl P, Liu F, Huguet R, Mullen C, Yamashita M, Zabrouskov V, Makarov A, Altelaar AF, Heck AJ. Benchmarking multiple fragmentation methods on an Orbitrap Fusion for top-down phospho-proteoform characterization. Analytical Chemistry (DOI: 10.1021/acs.analchem.5b00162)


Liu F, van Breukelen B, Heck AJ. Facilitating protein disulfide mapping by a combination of pepsin digestion, electron transfer higher energy dissociation (EThcD), and a dedicated search algorithm SlinkS. Molecular and Cellular Proteomics (DOI: 10.1074/mcp.O114.039057)


Olson AL*, Liu F*, Tucker AT, Goshe MB, Cavanagh J. Chemical crosslinking and LC/MS analysis to determine protein domain orientation: application to AbrB. Biochemical and biophysical research communications (DOI: 10.1016/j.bbrc.2012.12.124)

Liu F*, Wu C*, Sweedler JV, Goshe MB. An enhanced protein crosslink identification strategy using CID-cleavable chemical crosslinkers and LC/MS(n) analysis. Proteomics (DOI: 10.1002/pmic.201100352)

Liu F, Goshe MB. Combinatorial electrostatic collision-induced dissociative chemical cross-linking reagents for probing protein surface topology. Analytical Chemistry (DOI: 10.1021/ac101030w)